Protein Details: Cation channel sperm-associated auxiliary subunit TMEM249

Protein ID

ICDB_Pro_0009

Protein Name

Cation channel sperm-associated auxiliary subunit TMEM249

Gene Name

Tmem249

Organism

Mus musculus (Mouse)

Length

171 amino acids

AlphaFoldDB

AF-A0A2R8VHF7-F1-model_v4.pdb

Function

Auxiliary component of the CatSper complex; a complex involved in sperm cell hyperactivation.

Sequence

MLFIICLVFISCNVLREVKYQETWCFPAYGMVIGLWLMLSSIPQRRLVLNHTRGMYHFSIQGRTVCQGPMHLVYVRLALSSDAYGGRFFQLVLCGHKLEPLVLVQLSERYEQMEFLGRHLARKLNINYFDYLASSYRHVVRHWPLGASFSPGIVQRKTQVYTKSSVNDLDV

PDB Structures

7EEB

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Location

DOI ID

10.1371/journal.pbio.1000112; 10.1038/s41586-021-03742-6